Rabies virus quasispecies: Implications for pathogenesis
نویسندگان
چکیده
منابع مشابه
Rabies virus quasispecies: implications for pathogenesis.
Passage of the mouse-adapted rabies virus strain CVS-24 (where CVS is challenge virus standard) in BHK cells results in the rapid selection of a dominant variant designated CVS-B2c that differs genotypically and phenotypically from the dominant variant CVS-N2c present in mouse-brain- or neuroblastoma-cell-passaged CVS-24. The glycoprotein of CVS-B2c has 10 amino acid substitutions compared with...
متن کاملRabies virus matrix protein interplay with eIF3, new insights into rabies virus pathogenesis
Viral proteins are frequently multifunctional to accommodate the high density of information encoded in viral genomes. Matrix (M) protein of negative-stranded RNA viruses such as Rhabdoviridae is one such example. Its primary function is virus assembly/budding but it is also involved in the switch from viral transcription to replication and the concomitant down regulation of host gene expressio...
متن کاملRabies virus strains circulating in Bhutan: implications for control.
We report a molecular epidemiological study of rabies virus (RABV) strains circulating in animal populations in Bhutan, and investigate potential origins of these viruses. Twenty-three RABV isolates originating from dogs and other domestic animals were characterized by sequencing the partial nucleoprotein (N) gene (395 bp). Phylogenetic analysis was conducted and the Bhutanese isolates were com...
متن کاملPathogenesis of Rabies Virus Infection in Dogs: Do Dogs Recover from Clinical Rabies?
Dogs are the principal transmitter of rabies to man and animals in most countries of Africa, Asia and South America, where they are responsible for over 95% of the human rabies cases reported world-wide (WHO, 1989). The clinical course of rabies in dogs and that it could be transmitted by bite has been known for over 4000 years (Tierkel, 1975). After the virus is introduced to the body by bite ...
متن کاملDynamics of rabies virus quasispecies during serial passages in heterologous hosts.
To understand the mutations and genetic rearrangements that allow rabies virus infections of new hosts and adaptation in nature, the quasispecies structure of the nucleoprotein and glycoprotein genes as well as two noncoding sequences of a rabies virus genome were determined. Gene sequences were obtained from the brain and from the salivary glands of the original host, a naturally infected Euro...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1998
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.95.6.3152